[histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase EC#: 1.14.99.66; ChemWhat Code: 1375951

Product Name [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase
Example Structure Example Structure of [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase EC#: 1.14.99.66
Synonyms KDM1, LSD1, lysine-specific histone demethylase 1
EC Number 1.14.99.66
CAS Registry Number
Comments The enzyme specifically removes methyl groups from mono- and dimethylated lysine4 of histone 3. During the reaction the substrate is oxidized by the FAD cofactor of the enzyme to generate the corresponding imine, which is subsequently hydrolysed in the form of formaldehyde.The enzyme is similar to flavin amine oxidases, and differs from all other known histone lysine demethylases, which are iron(II)- and 2-oxoglutarate-dependent dioxygenases. The physiological electron acceptor is not known with certainty. In vitro the enzyme can use oxygen, which is reduced to hydrogen peroxide, but generation of hydrogen peroxide in the chromatin environment is unlikely as it will result in oxidative damage of DNA.
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