holo-[acyl-carrier-protein] synthase EC#: 2.7.8.7; ChemWhat Code: 1378925

Product Name holo-[acyl-carrier-protein] synthase
Example Structure Example Structure of holo-[acyl-carrier-protein] synthase EC#: 2.7.8.7
Synonyms (FAS)ACP, 4′-phosphopantetheinyl transferase, 4′-PP transferase, 4-phosphopantetheinyl transferase, 4-phosphopantetheinyl transferase 1, AASDHPPT, AcpS, AcpT, acyl carrier protein holoprotein (holo-ACP) synthetase, acyl carrier protein synthase, acyl carrier protein synthetase, acyl carrier protein-specific 4′-phosphopantetheinyl transferase, AT2G02770, BcPPT, Bli, BPSS2266, BSU03570, C1_09480W, ClbA, coenzyme A:fatty acid synthetase apoenzyme 4′-phosphopantetheine transferase, CpSFP-PPT, cytoplasmic type I FAS multienzyme, dpj, EntD, FKACPS, FKPPT1, FKPPT2, FKPPT3, FKPPT4, group II PPTase, gsp, holo ACP synthase, holo-ACP synthase, holo-ACP synthetase, holo-acyl carrier protein synthase, holo-[acyl-carrier-protein] synthase, holosynthase, human PPTase, L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase, LMJF_20_0830, LmPPT, mitochondrial phosphopantetheinyl transferase, mitochondrial type II fatty acid synthase, MtAcpS, mtPPT, MuPPT, NpgA, P-pant transferase, PaPcpS, PcpS, pcpS PA1165, phosphopantetheine:protein transferase, phosphopantetheinyl transferase, phosphopantetheinyl transferases, PobA, PP1183, PPT, PPT1, PPT2, Ppt2p, PPTase, PPTases, PptB, PptT, PswP, PTase, redU, Rv2794c, SchPPT, SCO6673, SePptII, Sfp, sfp lpa-8, Sfp-PPTase, Sfp-type PPTase, surfactin phosphopantetheinyl transferase, surfactin synthetase, TvPPT1, type I rat fatty acid synthase ACP, type II fatty acid synthase system, type-I fatty acid synthase FAS-A, type-II PPTase PptT, VabD, VibD, XabA, XALc_0101, YbtD
EC Number 2.7.8.7
CAS Registry Number 37278-30-1
Comments Requires Mg2+. All polyketide synthases, fatty-acid synthases and non-ribosomal peptide synthases require post-translational modification of their constituent acyl-carrier-protein (ACP) domains to become catalytically active. The inactive apo-proteins are converted into their active holo-forms by transfer of the 4′-phosphopantetheinyl moiety of CoA to the sidechain hydroxy group of a conserved serine residue in each ACP domain [3]. The enzyme from human can activate both the ACP domain of the human cytosolic multifunctional fatty acid synthase system (EC?2.3.1.85) and that associated with human mitochondria as well as peptidyl-carrier and acyl-carrier-proteins from prokaryotes [6]. Removal of the 4-phosphopantetheinyl moiety from holo-ACP is carried out by EC?3.1.4.14, [acyl-carrier-protein] phosphodiesterase.
Cofactor Mg2+
History
Reactions CoA-(4′-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3′,5′-bisphosphate + holo-[acyl-carrier-protein].

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