homoaconitate hydratase EC#: 4.2.1.36; ChemWhat Code: 1382294
| Product Name | homoaconitate hydratase |
| Example Structure |  |
| Synonyms | 2-hydroxy-3-carboxyadipate hydro-lyase, cis-Homoaconitase, HACN, HACNMj, Homoaconitase, Homoaconitate hydratase, Hydratase, homoaconitate, leuC, LYS4, lysF, MJ0499, MJ1271 |
| EC Number | 4.2.1.36 |
| CAS Registry Number | 9030-68-6 |
| Comments | Requires a [4Fe-4S] cluster for activity. The enzyme from the hyperthermophilic eubacterium?Thermus thermophilus?can catalyse the reaction shown above but cannot catalyse the previously described reaction, i.e. formation of homocitrate by hydration of?cis-homoaconitate. The enzyme responsible for the conversion of?cis-homoaconitate into homocitrate in?T. thermophilus?is unknown at present but the reaction can be catalysed in vitro using aconitate hydratase from pig (EC?4.2.1.3) [2]. |
| Cofactor | iron-sulfur |
| History | |
| Reactions | (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4- tricarboxylate + H(2)O. |
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