Human PCSK9 Protein, Accession#: Q8NBP7, CAS#: 3202-706-2206; ChemWhat Code: 1414695
Overview
| Product Description | Recombinant Human PCSK9 Protein is expressed from HEK293 with His tag at the C-terminal.It contains Gln31-Gln692. |
| Biotinylated |
Specification
| Target | PCSK9 |
| Synonyms | PC9; PCSK9; FH3; HCHOLA3; LDLCQ1; NARC-1 |
| Gene/Protein ID (Accession) | Q8NBP7 |
| Species | Human |
| Exact Sequence | Gln31-Gln692 |
| Molecular Weight | Due to autocatalytic cleavage, the protein release the pro-form (59 kDa) and mature form (14 kDa). Due to glycosylation, the protein migrates to 65-68 kDa (pro-form) and 15kDa (mature form) based on Tris-Bis PAGE result. |
| Activity | Immobilized Human PCSK9, His Tag at 2ug/ml (100ul/Well) on the plate. Dose response curve for Anti-PCSK9 antibody, hFc Tag with the EC50 of 0.16ug/ml determined by ELISA (QC Test). The affinity constant of 0.35 nM as determined in SPR assay (Biacore T200). See testing image for detail. |
| Product Tag | C-His |
| Express System | HEK293 |
| Endotoxin | Less than 1EU per ug by the LAL method. |
Shipping, Reconstitution & Storage
| Form | Liquid |
| Shipping | Shipped with blue ice. |
| Formulation | Supplied as 0.22um filtered solution in 20mM PB, 300mM NaCl, 10% Glycerol (pH 7.4). |
| Reconstitution | |
| Stability and Storage | Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please avoid repeated freeze-thaw cycles. |
Validation Spectrums
| Spectrums |  |
Buy Reagent | |
| ChemWhat 1414695 | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
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