hydroperoxy icosatetraenoate isomerase EC#: 5.4.4.7; ChemWhat Code: 1383365
| Product Name | hydroperoxy icosatetraenoate isomerase |
| Example Structure |  |
| Synonyms | ALOXE3, eLOX-3, eLOX3, epidermal lipoxygenase-3, epidermal LOX type 3, hepoxilin synthase |
| EC Number | 5.4.4.7 |
| CAS Registry Number | |
| Comments | Binds Fe2+. The enzyme from mammals accepts a range of hydroperoxy icosatetraenoates producing one or several different hydroxy epoxy icosatrienoates. The human enzyme has highest activity with (12R)-HPETE producing (5Z,8R,9E,11R,12R,14Z)-8-hydroxy-11,12-epoxyicosa-5,9,14-trienoate, followed by (12S)-HPETE producing (5Z,8Z,10R,11S,12S,14Z)-10-hydroxy-11,12-epoxyicosa-5,8,14-trienoate and (5Z,8R,9E,11S,12S,14Z)-8-hydroxy-11,12-epoxyicosa-5,9,14-trienoate [1]. The mouse enzyme has highest activity with (8S)-HPETE, producing (5Z,8S,9S,10R,11Z,14Z)-10-hydroxy-8,9-epoxyicosa-5,11,14-trienoate [2]. The enzymes also have the activity of EC?4.2.1.152, hydroperoxy icosatetraenoate dehydratase. |
| Cofactor | Fe2+ |
| History | |
| Reactions | A hydroperoxy icosatetraenoate = a hydroxy epoxy icosatrienoate. |
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