isocitrate-homoisocitrate dehydrogenase EC#: 1.1.1.286; ChemWhat Code: 1373387

Product Name isocitrate-homoisocitrate dehydrogenase
Example Structure Example Structure of isocitrate-homoisocitrate dehydrogenase EC#: 1.1.1.286
Synonyms 3-carboxy-2-hydroxyadipate dehydrogenase, HICDH, homoisocitrate dehydrogenase, isocitrate-homoisocitrate dehydrogenase, More, Saci_2375, TK0280
EC Number 1.1.1.286
CAS Registry Number
Comments Requres Mn2+ and K+ or NH4+ for activity. Unlike EC 1.1.1.41, isocitrate dehydrogenase (NAD+) and EC 1.1.1.87, homoisocitrate dehydrogenase, this enzyme, from Pyrococcus horikoshii, can use both isocitrate and homoisocitrate as substrates. The enzyme may play a role in both the lysine and glutamate biosynthesis pathways.
Cofactor (1)NH4+ or K+ (2)Mn2+
History
Reactions (1) Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + Nadh. (2) (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD(+) = 2-oxoadipate + CO(2) + Nadh.

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