Levothyroxine sodium CAS#: 55-03-8(25416-65-3); ChemWhat Code: 52875

Names & IdentifiersNew LiteratureSpectral Properties
Chemical & Physical PropertiesNew PatentsMarket Information
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Names & Identifiers

Product NameLevothyroxine sodium
Molecular StructureLevothyroxine sodium CAS 55-03-8(25416-65-3)
CAS Registry Number 55-03-8(25416-65-3)
EINECS Number200-221-4
SynonymsLevothyroxine Sodium [INN] [USAN];(2S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophénoxy)-3,5-diiodophényl]propanoate de sodium [French] [ACD/IUPAC Name];200-221-4 [EINECS]; 216-080-7 [EINECS];[RN];Eltroxin [Trade name];Euthyrox [Trade name];L-3,3′,5,5′-Tetraiodothyronine Sodium Salt;Levaxin [Trade name];Levothroid [Trade name];lévothyroxine sodique [French] [INN];levothyroxinum natricum [Latin] [INN];levotiroxina de sodio [Spanish] [INN];Levotiroxina sodica [Spanish] [INN];Levoxyl [Trade name];L-Thyroxine monosodium salt;L-Thyroxine sodium salt [USP];L-Tyrosine, O- (4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, monosodium salt;L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt (1:1) [ACD/Index Name];Natrium-(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodphenoxy)-3,5-diiodphenyl]propanoat [German] [ACD/IUPAC Name];O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine Monosodium Salt;Oroxine [Trade name];Sodium (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate [ACD/IUPAC Name];Sodium Levothyroxine;Sodium l-thyroxin;SODIUM L-THYROXINE; Synthroid [Trade name];Thyro-Tabs [Trade name]; левотироксин натрия [Russian] [INN];ليفوثيروكسين صوديوم [Arabic] [INN];左甲状腺素钠 [Chinese] [INN];3,3´,5,5´-Tetraiodo-L-thyronine sodium salt;3,3′,5,5′-Tetraiodo-L-thyronine, sodium salt;3,3,5,5-Tetraiodo-L-thyronine sodium salt;5721845 [Beilstein];Dathroid;DL-THYROXINE SODIUM SALT;EINECS 200-221-4;EINECS 216-080-7;Laevoxin;Letter;Levoroxine;Levo-T;Levothyroid;Levothyrox;levothyroxine sodique;Levothyroxine sodique [INN-French];Levothyroxinesodium;Levothyroxin-natrium;levothyroxinum natricum;Levothyroxinum natricum [INN-Latin];levotiroxina de sodio;Levotiroxina sodica [INN-Spanish]
Levoxine;L-thyroxine sodium;L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, monosodium salt;MFCD00002596;Novothyrox;Powdered Thyroid;QA-1528;Ro-thyroxine;Roxstan;sodium (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]propanoate;sodium (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]propionate;sodium (S)-2-amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoate;SODIUM LEVOTHYROXINE(1-);sodium O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosinate;Sodium thyroxin;Sodium thyroxinate;Sodium thyroxine;Sodiumlevothyroxine;Sodium-L-thyroxine;Soloxine;ST5330577;Synthroid sodium;Tetroid;Thyradin [Wiki];Thyradin S;Thyrax [Wiki];Thyroid [Wiki];Thyrol L;Thyronamin;Thyroxevan;Thyroxin sodium;Thyroxine sodique;thyroxine sodium;THYROXINE, MONOSODIUM SALT; L- Thyroxinum natricum;Tiroidina;tirosint;Unithroid;
MDL NumberMFCD06408007
Molecular FormulaC15H10I4NNaO4
Molecular Weight798.852 
SMILESc1c(cc(c(c1I)Oc2cc(c(c(c2)I)O)I)I)C[C@@H](C(=O)[O-])N.[Na+]
Std. InChiInChI=1S/C15H11I4NO4.Na/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;/h1-2,4-5,12,21H,3,20H2,(H,22,23);/q;+1/p-1/t12-;/m0./s1
Std. InChIKeyYDTFRJLNMPSCFM-YDALLXLXSA-M

Chemical & Physical Properties

AppearanceOff-white to buff colored powder

Safety & Hazards

Symbolhealth-hazardHealth Hazard
SignalWarning

GHS Hazard Statements		 Aggregated GHS information provided by 46 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
H361 (93.48%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
H372 (93.48%): Causes damage to organs through prolonged or repeated exposure [DangerSpecific target organ toxicity, repeated exposure]
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
(The corresponding statement to each H-code can be found here.)
Precautionary Statement CodesP201, P202, P260, P264, P270, P281, P308+P313, P314, P405, and P501
(The corresponding statement to each P-code can be found here.)
ToxicityAcute toxicity
No data available
Inhalation: No data available
Dermal: No data available
No data available
Skin corrosion/irritation
No data available
Serious eye damage/eye irritation
No data available
Respiratory or skin sensitisation
No data available
Germ cell mutagenicity
No data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is
identified as probable, possible or confirmed human carcinogen by IARC.
ACGIH: No component of this product present at levels greater than or equal to 0.1% is
identified as a carcinogen or potential carcinogen by ACGIH.
NTP: No component of this product present at levels greater than or equal to 0.1% is
identified as a known or anticipated carcinogen by NTP.
OSHA: No component of this product present at levels greater than or equal to 0.1% is
on OSHA’s list of regulated carcinogens.
Reproductive toxicity
No data available
No data available
Specific target organ toxicity – single exposure
No data available
Specific target organ toxicity – repeated exposure
No data available
Aspiration hazard
No data available
Additional Information
RTECS: Not available
To the best of our knowledge, the chemical, physical, and toxicological properties have not
been thoroughly investigated.
Stomach – Irregularities – Based on Human Evidence
Stomach – Irregularities – Based on Human Evidence
Transportation InformationADR/RID:
Not dangerous goods
IMDG: 
Not dangerous goods
IATA
Not dangerous goods
WGK Germany3
For more detailed information, please visit ECHA C&L website
Source: European Chemicals Agency (ECHA)
License Note: Use of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: “Source: European Chemicals Agency, http://echa.europa.eu/”. Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page.
License URL: https://echa.europa.eu/web/guest/legal-notice
Record Name: (1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate
URL: https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/213446
Description: The information provided here is aggregated from the “Notified classification and labelling” from ECHA’s C&L Inventory. Read more: https://echa.europa.eu/information-on-chemicals/cl-inventory-database

New Literature

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New Patents

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Transportation, Storage & Usage

TransportationUnder the room temperature and away from light
HS Code293790
StorageStore in a closed container at room temperature at 25℃~30 ℃.
Shelf Life2 years
UsageIt has a large potential as a replacement for terephthalic acid, a widely used component in various polyesters, such as polyethylene terephthalate (PET) and polybutyleneterephthalate (PBT). PET has a market size approaching 4 billion lb/yr, and PBT is almost a billion lb/yr. The market value of PET polymers varies depending on the application, but is in the range of $1.00 – 3.00/lb for uses as films and thermoplastic engineering polymers. The versatility of FDCA is also seen in the number of derivatives available via relatively simple chemical transformations. Selective reduction can lead to partially hydrogenated products,such as 2,5-dihydroxymethylfuran, and fully hydrogenated materials, such as 2,5-bis(hydroxymethyl)tetrahydrofuran. Both of these latter materials can serve as alcohol components in the production of new polyester, and their combination with FDCA would lead to a new family of completely biomass-derived products. Extension of these concepts to the production of new nylons, either through reaction of FDCA with diamines, or through the conversion of FDCA to 2,5-bis(aminomethyl)tetrahydrofuran could address a market of almost 9 billion lb/yr, with product values between $0.85 and 2.20/lb, depending on the application. FDCA can also serve as a starting material for the production of succinic acid, whose utility is elsewhere.

Spectral Properties

IR of 2,5-Furandicarboxylic acid CAS#: 55-03-8(25416-65-3) IR of Levothyroxine sodium CAS 55-03-8

Market Information

Reference Price(The average price based on Chemwhat’s market research)USD

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