low-specificity L-threonine aldolase EC#: 4.1.2.48; ChemWhat Code: 1382101

Product Name low-specificity L-threonine aldolase
Example Structure Example Structure of low-specificity L-threonine aldolase EC#: 4.1.2.48
Synonyms GLY1, GlyA, L-TA, L-threonine aldolase, low specificity L-TA, low specificity threonine aldolase, Low-specificity L-threonine aldolase, LTA, LtaE, serine hydroxy-methyl transferase, SHMT, threonine aldolase
EC Number 4.1.2.48
CAS Registry Number
Comments Requires pyridoxal phosphate. The low-specificity?L-threonine aldolase can act on both?L-threonine and?L-allo-threonine [1,2]. The enzyme from?Escherichia coli?can also act on?L-threo-phenylserine and?L-erythro-phenylserine [4]. The enzyme can also catalyse the aldol condensation of glycolaldehyde and glycine to form 4-hydroxy-L-threonine, an intermediate of pyridoxal phosphate biosynthesis [3]. Different from EC?4.1.2.5,?L-threonine aldolase, and EC?4.1.2.49,?L-allo-threonine aldolase.
Cofactor pyridoxal 5′-phosphate
History
Reactions (1) L-threonine = glycine + acetaldehyde. (2) L-allo-threonine = glycine + acetaldehyde.

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