[methionine synthase] reductase EC#: 1.16.1.8; ChemWhat Code: 1375966

Product Name [methionine synthase] reductase
Example Structure Example Structure of [methionine synthase] reductase EC#: 1.16.1.8
Synonyms EC 2.1.1.135, Methionine synthase cob(II)alamin reductase (methylating), Methionine synthase reductase, MSR, MTRR, NADPH-dependent diflavin oxidoreductase, Reductase, methionine synthase
EC Number 1.16.1.8
CAS Registry Number 207004-87-3
Comments In humans, the enzyme is a flavoprotein containing FAD and FMN. The substrate of the enzyme is the inactivated cobalt(II) form of EC 2.1.1.13, methionine synthase. Electrons are transferred from NADPH to FAD to FMN. Defects in this enzyme lead to hereditary hyperhomocysteinemia.
Cofactor FMN;FAD
History
Reactions 2 [methionine synthase]-methylcob(I)alamin + 2 S-adenosylhomocysteine + NADP(+) = 2 [methionine synthase]-cob(II)alamin + Nadph + 2 S-adenosyl-L- methionine.

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