Identification	Physical Data	Spectra
Route of Synthesis (ROS)	Safety and Hazards	Other Data

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Identification

Product Name	Methotrexate Hydrate EP Impurity B
Molecular Structure
CAS Registry Number	1217459-90-9
EINECS Number
MDL Number
Beilstein Registry Number
Synonyms	(2S)-2-[[4-[[(2,4-diaminopteridin-6-yl)methyl]amino]benzoyl]amino]pentanedioic acid hydrate (as per EP) ; (S)-2-{4-[(2,4-diaminopteridin-6-yl)methylamino]benzamido}pentanedioic acid hydrate (as per USP)
Molecular Formula	C19H20N8O5 : H2O
Molecular Weight	440.4 : 18.0
InChI
InChI Key
Canonical SMILES	NC1=NC(N)=C2C(N=CC(CNC3=CC=C(C(N[C@]([H])(C(O)=O)CCC(O)=O)=O)C=C3)=N2)=N1.O

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Physical Data

Appearance	No data available
Solubility	No data available
Flash Point	No data available
Refractive index	No data available
Sensitivity	No data available
Melting Point	No data available

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Spectra

No data available

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Route of Synthesis (ROS)

No data available

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Safety and Hazards

No data available

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Other Data

HS Code	382290
Storage	At room temperature and away from light
Related Chemicals	54-62-6 (free base)

Use Pattern

Methotrexate Hydrate EP Impurity B is chemically (2S)-2-[[4-[[(2,4-diaminopteridin-6-yl)methyl]amino]benzoyl]amino]pentanedioic acid hydrate (as per EP) ; (S)-2-{4-[(2,4-diaminopteridin-6-yl)methylamino]benzamido}pentanedioic acid hydrate (as per USP). It is also known as Methotrexate USP Related Compound B ; (4-Aminofolic acid, Aminopterin (EP)). Methotrexate Hydrate EP Impurity B is supplied with detailed characterization data compliant with regulatory guideline. Methotrexate Hydrate EP Impurity B can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Methotrexate. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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