[methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase
Example Structure
Synonyms
Co-methyl-5-hydroxybenzimidazolylcobamide:2-mercapto-ethanesulphonic acid methyltransferase, methanol-specific methyltransferase 2, methanol:cob(I)alamin methyltransferase, methanol:coenzyme M methyltransferase, methylcobalamin:coenzyme M methyltransferase, methylcobamide:coenzyme M methyltransferase, methylcobamide:CoM methyltransferase, methyltransferase 2, MT2, MT2-A, MT2-M, mtaA
EC Number
2.1.1.246
CAS Registry Number
Comments
The enzyme, which is involved in methanogenesis from methanol, catalyses the transfer of a methyl group from a corrinoid protein (see EC 2.1.1.90, methanol¡ªcorrinoid protein Co-methyltransferase), where it is bound to the cobalt cofactor, to coenzyme M, forming the substrate for EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase, the enzyme that catalyses the final step in methanogenesis. Free methylcob(I)alamin can substitute for the corrinoid protein in vitro [5].
Cofactor
History
Reactions
A [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme m = methyl-CoM + a [Co(I) methanol-specific corrinoid protein].
![Example Structure of [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase EC#: 2.1.1.246](/wp-content/uploads/enzyme-structure/2.1.1.246.jpg)