methylenetetrahydrofolate reductase (ferredoxin) EC#: 1.5.7.1; ChemWhat Code: 1374471

Product Name methylenetetrahydrofolate reductase (ferredoxin)
Example Structure Example Structure of methylenetetrahydrofolate reductase (ferredoxin) EC#: 1.5.7.1
Synonyms 5,10-methylenetetrahydrofolate reductase, metF, methylene-H4F reductase, methylenetetrahydrofolate reductase
EC Number 1.5.7.1
CAS Registry Number
Comments An iron-sulfur flavoprotein that also contains zinc. The enzyme from Clostridium formicoaceticum catalyses the reduction of methylene blue, menadione, benzyl viologen, rubredoxin or FAD with 5-methyltetrahydrofolate and the oxidation of reduced ferredoxin or FADH2 with 5,10-methylenetetrahydrofolate. However, unlike EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H], there is no activity with NAD(P)H.
Cofactor iron-sulfur;Zn2+;flavoprotein
History
Reactions 5-methyltetrahydrofolate + 2 oxidized ferredoxin = 5,10- methylenetetrahydrofolate + 2 reduced ferredoxin + 2 H(+).

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