methyltransferase cap1 EC#: 2.1.1.57; ChemWhat Code: 1376210
| Product Name | methyltransferase cap1 |
| Example Structure |  |
| Synonyms | (nucleoside-2′-O-)-methyltransferase, (nucleoside-2’O)-methyltransferase, 2′-O methyltransferase, 2′-O MTase, 2′-O-methyltransferase, 2′-O-MTase, 2’O methyltransferase, 2’O-MTase, 2’OMTases, cap-specific 2′-O-methyltransferase, cap1 2-O’-ribose methyltransferase, EC 2.1.1.58, FtsJ methyltransferase domain-containing 2, FTSJD2, ISG95, L protein domain VI, large polymerase protein domain VI, messenger ribonucleate nucleoside 2′-methyltransferase, messenger RNA (nucleoside-2′-)-methyltransferase, methyltransferase, messenger ribonucleate nucleoside 2′-, mRNA (nucleoside-2′-O)-methyltransferase, mRNA 5′ cap-specific (nucleoside-2′-O)-methyltransferase, mRNA cap (nucleoside-2′-O)-methyltransferase, mRNA cap methyltransferase, mRNA cap-specific 2′-O-methyltransferase, MT57, Mtr1, nonstructural protein 16, nonstructural protein 16 methyltransferase, nonstructural protein 5 methyltransferase, NS5, NS5 MTase, NS5MTase, nsp10/16 complex, nsp10/nsp16 complex, nsp16, nsp16 protein, nsp16/nsp10 protein complex, ribose 2′-O methyltransferase, RNA (nucleoside-2’O)-methyltransferase, RNA cap 2′-O-methyltransferase, RNA cap 2′-O-MTase, RNA cap 2’O-MTase, S-adenosyl-L-methionine-dependent mRNA cap MTase, TbMT48, TbMT57, VP39, VP4 |
| EC Number | 2.1.1.57 |
| CAS Registry Number | 61970-02-3 |
| Comments | This enzyme catalyses the methylation of the ribose on the first transcribed nucleotide of mRNA or snRNA molecules, which may be either guanosine or adenosine. This methylation event is known as cap1, and occurs in all mRNAs and snRNAs of higher eukaryotes, including insects, vertebrates and their viruses. The human enzyme can also methylate mRNA molecules that lack methylation on the capping 5′-triphosphoguanosine [6]. |
| Cofactor | |
| History | |
| Reactions | S-adenosyl-L-methionine + a 5′-(N(7)-methyl 5′-triphosphoguanosine)- (purine-ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5′-(N(7)- methyl 5′-triphosphoguanosine)-(2′-O-methyl-purine-ribonucleotide)- [mRNA]. |
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