mitogen-activated protein kinase kinase kinase EC#: 2.7.11.25; ChemWhat Code: 1379029

Product Name mitogen-activated protein kinase kinase kinase
Example Structure Example Structure of mitogen-activated protein kinase kinase kinase EC#: 2.7.11.25
Synonyms (JNK)/stress-activated protein kinase-associated protein 1, A-Raf, angle1, apoptosis signal-regulated kinase 1, apoptosis signal-regulating kinase, apoptosis signal-regulating kinase 1, apoptosis signal-regulating kinase 2, ASK1, ASK2, At4g08480, At4g08500, B-Raf, B-Raf kinase, BcOs4, BnaM3K18, BnaM3K19, BnaMAPKKK, BnaMAPKKK18.1, BnaMAPKKK19.1, BnaMAPKKK4.2, BRAF, BRAF protein serine/threonine kinase, c-mos, C-Raf, cancer osaka thyroid, COT, COT30-397, COT30-467, D-MEKK1, DLK, Dual leucine zipper bearing kinase, dual leucine zipper-bearing kinase, extracellular signal-regulated kinase kinase kinase-1, fertilization-related kinase 1, fertilization-related kinase 2, Frk1, Frk2, GCKR, germinal center kinase-related enzyme, HsNIK, ILA1, JSAP1, Jun N-terminal kinase kinase kinase, Jun N-terminal protein kinase, Leucine-zipper protein kinase, LZK, M3Kalpha, MAP 3-kinase, MAP kinase kinase kinase, MAP kinase kinase kinase 1, MAP kinase kinase kinase 2, MAP kinase kinase kinase 3, MAP kinase kinase kinase mkh1, MAP kinase kinase kinase SSK2, MAP kinase kinase kinase win1, MAP kinase kinase kinase wis4, MAP/ERK kinase kinase 1, MAP3K, MAP3K1, MAP3K12, MAP3K6, MAP3K7, MAP3Ka, MAPK kinase kinase, MAPK-upstream kinase, MAPK/ERK kinase kinase 1, MAPK/ERKkinase kinase 3, MAPKK kinase, MAPKKK, MAPKKK4, MAPKKK6, MAPKKKalpha, MCK1, Mek kinase, MEK kinase 1, MEK kinase 3, MEKK1, MEKK2, MEKK3, MEKK4, MEKK5, MEKK8, mik-1, mitogen activated protein kinase kinase kinase, mitogen-activated protein kinase kinase kinase, mitogen-activated protein kinase kinase kinase 1, mitogen-activated protein kinase kinase kinase 3, mitogen-activated protein kinase kinase kinase 4, mitogen-activated protein kinase kinase kinase 6, mitogen-activated protein kinase kinase kinase kinase, mitogen-activated protein kinase kinase kinase-1, mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 1, mitogen-activated protein kinase/extracellular-regulated kinase kinase kinase-3, mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase kinase 1, mitogen-activated protein/ERK kinase kinase 3, Mixed Lineage Kinase, mixed lineage kinase 4, Mkh1, MKKK, MKL3, MLK, MLK-like mitogen-activated protein triple kinase, MLK1, MLK2, MLK3, MLK4, MLTKalpha, More, Mos, MTK1, MUK, NF-kappa beta-inducing kinase, NSY-1, OMTK1, oxidative stress-activated MAP triple-kinase 1, protein kinase byr2, putative mitogen-activated protein kinase 1, Raf, Raf-1, Raf-like MAPKKK, Raf10, Raf11, ScFRK1, Serine/threonine protein kinase NIK, serine/threonine-protein kinase STE11, Ssk2, SSk2 MAPK kinase kinase, Ssk22p, Ssk2p, Ste11, Ste11p, summ1, suppressor of mkk1 mkk2 1, TAK1, TAK1 (three isoforms termed A,B and C), TAO, TAO kinase, TAO1-2, TAO2-1, TGF-beta-activated kinase-1, TGFalpha activated kinase, TGFbeta activated kinase 1, TGFbeta-activated kinase 1, Thousand And One kinase, Tlp2, TPL-2, transforming growth factor beta-activated kinase 1, TTP kinase, tumor progression locus-2, tumour progression locus 2, Wak1, Wik1, Win1, Wis4, YODA, ZAK, ZPK, ZPK/DLK
EC Number 2.7.11.25
CAS Registry Number
Comments This enzyme phosphorylates and activates its downstream protein kinase, EC?2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) but requires MAPKKKK for activation. Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras. While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway [2]. Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
Cofactor
History
Reactions Atp + a protein = adp + a phosphoprotein.

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