N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase EC#: 2.8.2.33; ChemWhat Code: 1379119

Product Name N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
Example Structure Example Structure of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase EC#: 2.8.2.33
Synonyms B-cell RAG associated protein, BRAG, GalNAc 4-sulfate 6-O-sulfotransferase, GalNAc(4S)-6-O-sulfotransferase, GalNAc4S 6-O-sulfotransferase, GalNAc4S-6ST, GALNAC4S-6ST/BRAG, GalNAc4S6ST, mGalNAc4S-6ST, N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
EC Number 2.8.2.33
CAS Registry Number
Comments The enzyme is activated by divalent cations and reduced glutathione. The enzyme from human transfers sulfate to position 6 of both internal residues and non-reducing terminal GalNAc 4-sulfate residues of chondroitin sulfate. Oligosaccharides derived from chondroitin sulfate also serve as acceptors but chondroitin sulfate E, keratan sulfate and heparan sulfate do not. Differs from EC?2.8.2.17, chondroitin 6-sulfotransferase, in being able to use both chondroitin and dermatan as effective substrates.
Cofactor
History
Reactions (1) 3-phospho-5-adenylyl sulfate + [dermatan]-4-O-sulfo-N- acetylgalactosamine = adenosine 3′,5′-bisphosphate + [dermatan]-4,6-di-O- sulfo-N-acetyl-D-galactosamine. (2) 3-phospho-5-adenylyl sulfate + [chondroitin]-4-O-sulfo-N- acetylgalactosamine = adenosine 3′,5′-bisphosphate + [chondroitin]-4,6- di-O-sulfo-N-acetyl-D-galactosamine.

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