nicotinate phosphoribosyltransferase EC#: 6.3.4.21; ChemWhat Code: 1383848
| Product Name | nicotinate phosphoribosyltransferase |
| Example Structure |  |
| Synonyms | EC 2.4.2.11, LOC_Os03g62110, More, NA phosphoribosyltransferase, NAPRT, NaPRT1, NAPRTase, niacin ribonucleotidase, nicotinate phosphoribosyltransferase, nicotinate phosphoribosyltransferases, nicotinate-nucleotide:pyrophosphate phospho-alpha-D-ribosyltransferase, nicotinic acid mononucleotide glycohydrolase, nicotinic acid mononucleotide pyrophosphorylase, nicotinic acid phosphoribosyltransferase, NPRTase, pncB |
| EC Number | 6.3.4.21 |
| CAS Registry Number | 9030-26-6 |
| Comments | The enzyme, which is involved in pyridine nucleotide recycling, can form ¦Â-nicotinate?D-ribonucleotide and diphosphate from nicotinate and 5-phospho-¦Á-D-ribose 1-diphosphate (PRPP) in the absence of ATP. However, when ATP is available the enzyme is phosphorylated resulting in a much lower?Km?for nicotinate. The phospho-enzyme is hydrolysed during the transferase reaction, regenerating the low affinity form. The presence of ATP shifts the products/substrates equilibrium from 0.67 to 1100 [4]. |
| Cofactor | |
| History | |
| Reactions | Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + Atp + H(2)O = beta- nicotinate D-ribonucleotide + diphosphate + Adp + phosphate. |
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