pancreatic ribonuclease EC#: 4.6.1.18; ChemWhat Code: 1382996
| Product Name | pancreatic ribonuclease |
| Example Structure |  |
| Synonyms | alkaline ribonuclease, bovine pancreatic ribonuclease A, bovine seminal RNase, BS-RNase, Ceratitis capitata alkaline ribonuclease, EC 2.7.7.16, EC 3.1.4.22, EC-RNase, Ecp, eosinophil cationic protein, Eosinophil-derived neurotoxin, gene S glycoproteins, gene S locus-specific glycoproteins, glycoproteins, gene S locus-specific, glycoproteins, S-genotype-asssocd, glycoproteins, SLSG, glycoproteins, specific or class, gene S, glycoproteins, specific or class, SLSG (gene S locus-specific glycoprotein), HP-RNase, HPR, More, nuclease, ribo-, onconase, pancreas ribonuclease A, pancreatic ribonuclease, pancreatic ribonuclease 1, pancreatic ribonuclease A, pancreatic RNase, PE5, ranpirnase, ribonuclease, ribonuclease A, ribonuclease I, Ribonuclease US, ribonuclease W1, ribonucleate 3′-pyrimidino-oligonucleotidohydrolase, ribonucleic phosphatase, RL1, RNase, RNase 1, RNase 2, RNase 3, RNase 4, RNase 5, RNase A, RNase A2, RNase I, RNase ZF-3e, RNase-A, RNase1, RNase9, RnaseA, S-RNase, seminal ribonuclease, Seminal RNase, SLSG glycoproteins, type I RNase A, type II RNase A |
| EC Number | 4.6.1.18 |
| CAS Registry Number | |
| Comments | Specifically cleaves at the 3′-side of pyrimidine (uracil or cytosine) phosphate bonds in RNA. The reaction takes place in two steps, with the 2′,3′-cyclic phosphodiester intermediates released from the enzyme at the completion of the first step. Hydrolysis of these cyclic compounds occurs at a much slower rate through a reversal of the first step, in which the -OH group of water substitutes for the 2′-OH group of the ribose used in the first step, and does not take place until essentially all the susceptible 3′,5′-phosphodiester bonds have been cyclised. The enzyme can act as an endo- or exo ribonuclease. Formerly EC?2.7.7.16, EC?3.1.4.22?and EC?3.1.27.5. |
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