phosphomethylpyrimidine synthase EC#: 4.1.99.17; ChemWhat Code: 1382214

Product Name phosphomethylpyrimidine synthase
Example Structure Example Structure of phosphomethylpyrimidine synthase EC#: 4.1.99.17
Synonyms 2-methyl-4-amino-5-hydroxymethylpyrimidine phosphate synthase, 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase, AtTHIC, HMP phosphate synthase, HMP-P synthase, LeThiC, Thi5p, thiC
EC Number 4.1.99.17
CAS Registry Number
Comments Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable?S-adenosyl-L-methionine molecule. The first stage of catalysis is reduction of the?S-adenosyl-L-methionine to produce?L-methionine and a 5′-deoxyadenosin-5′-yl radical that is crucial for the conversion of the substrate. Part of the pathway for thiamine biosynthesis.
Cofactor iron-sulfur
History
Reactions 5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphomethyl)pyrimidine + 5′-deoxyadenosine + L-methionine + formate + Co.

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