Identification	Physical Data	Spectra
Route of Synthesis (ROS)	Safety and Hazards	Other Data

---

Identification

Product Name	Pivmecillinam
IUPAC Name	2,2-dimethylpropanoyloxymethyl (2S,5R,6R)-6-(azepan-1-ylmethylideneamino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
Molecular Structure
CAS Registry Number	32886-97-8
EINECS Number	251-278-7
Synonyms	6β-azepan-1-ylmethyleneamino-penicillanic acid 2,2-dimethyl-propionyloxymethyl ester, amdinocillin pivoxil, pivmecillinam
Molecular Formula	C21H33N3O5S.HCl
Molecular Weight	476.03
InChI	InChI=1S/C21H33N3O5S.ClH/c1-20(2,3)19(27)29-13-28-18(26)15-21(4,5)30-17-14(16(25)24(15)17)22-12-23-10-8-6-7-9-11-23;/h12,14-15,17H,6-11,13H2,1-5H3;1H/t14-,15+,17-;/m1./s1
InChI Key	UHPXMYLONAGUPC-WKLLBTDKSA-N
Canonical SMILES	CC1(C(N2C(S1)C(C2=O)N=CN3CCCCCC3)C(=O)OCOC(=O)C(C)(C)C)C

Patent Information

No data available

---

Physical Data

Appearance	White or almost white crystalline powder
Solubility	DMSO: soluble5mg/mL, clear (warmed)

Melting Point, °C

118 – 119

117 – 119

119 – 120

---

Spectra

No data available

For more detailed information, please visit ECHA C&L website

Source: European Chemicals Agency (ECHA) License Note: Use of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: “Source: European Chemicals Agency, http://echa.europa.eu/”. Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page. License URL: https://echa.europa.eu/web/guest/legal-notice Record Name: (1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate URL: https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/213446 Description: The information provided here is aggregated from the “Notified classification and labelling” from ECHA’s C&L Inventory. Read more: https://echa.europa.eu/information-on-chemicals/cl-inventory-database

---

Route of Synthesis (ROS)

Conditions	Yield
entspr.6-Amin, Hexamethylenimin, HC(OC2H5)3;
6-Amino-penizillansaeure (6-AP) 1.Pivaloyloxymethylchlorid,DMF, Triethylamin 2. /BRN= 163211/, CHCl3, Triethylamin;
/BRN= 894181/, DMF, Triethylamin, Pivaloyloxymethylchlorid (S.193);
Entspr. Amin, Acyl.;
Amin, R2NCH=X;

---

Safety and Hazards

No data available

---

Other Data

Transportation	Under the room temperature and away from light
Storage	Under the room temperature and away from light
Shelf Life	1 year
Market Price	USD

Druglikeness
Lipinski rules component
Molecular Weight	439.576
logP	2.671
HBA	8
HBD	0
Matching Lipinski Rules	4
Veber rules component
Polar Surface Area (PSA)	113.81
Rotatable Bond (RotB)	8
Matching Veber Rules	2

Use Pattern

Pivmecillinam CAS# 32886-97-8 is an orally active prodrug of mecillinam, an extended-spectrum penicillin antibiotic.

Pivmecillinam is the pivaloyloxymethyl ester of mecillinam.

Pivmecillinam is only considered to be active against Gram-negative bacteria, and is used primarily in the treatment of lower urinary tract infections.

It as the first-line drug of choice for empirical treatment of acute cystitis.

It has also been used to treat paratyphoid fever and shigellosis.

Buy Reagent
No reagent supplier?	Send quick inquiry to ChemWhat
Want to be listed here as a reagent supplier? (Paid service)	Click here to contact ChemWhat

Approved Manufacturers
Caming Pharmaceutical Ltd	http://www.caming.com/
Want to be listed as an approved manufacturer (Requires approvement)?	Please download and fill out this form and send back to approved-manufacturers@chemwhat.com

Contact Us for Other Help
Contact us for other information or services	Click here to contact ChemWhat