polo kinase EC#: 2.7.11.21; ChemWhat Code: 1379025
| Product Name | polo kinase |
| Example Structure |  |
| Synonyms | Cdc5, Cdc5-polo kinase, Cdc5p, cell cycle protein kinase CDC5/MSD2, cytokine-inducible serine/threonine-protein kinase, FGF-inducible kinase, Fnk, for polo-like kinase 4, hPlk1, hPlk5, HsPlk1, More, mPlk5, PLK, PLK-1, Plk-2, Plk1, PLK1 kinase, Plk2, Plk3, PLK4, Plk5, Plo1, Plx1, Polo kinase, polo related kinase, polo-kinase, polo-like kinase, Polo-like kinase 1, polo-like kinase 2, polo-like kinase 3, polo-like kinase 4, polo-like kinase 5, polo-like kinase Cdc5, polo-like kinase PLK-1, polo-like kinase-1, polo-like kinase-2, polo-like-kinase 1, Prk, Proliferation-related kinase, protein kinase polo, Sak, serine/threonine-protein kinase PLK, serine/threonine-protein kinase plk-1, serine/threonine-protein kinase plk-2, serine/threonine-protein kinase plk-3, serine/threonine-protein kinase plo1, serine/threonine-protein kinase SNK, SMK/PLK-AKIN kinase, SmPlk1, TbPLK, zPlk1 |
| EC Number | 2.7.11.21 |
| CAS Registry Number | |
| Comments | The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein [2]. |
| Cofactor | |
| History | |
| Reactions | Atp + a protein = adp + a phosphoprotein. |
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