Pramiracetam CAS#: 68497-62-1; ChemWhat Code: 122540
Identification
| Product Name | Pramiracetam |
| IUPAC Name | N-[2-[di(propan-2-yl)amino]ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide |
| Molecular Structure |  |
| CAS Registry Number | 68497-62-1 |
| EINECS Number | No data available |
| MDL Number | No data available |
| Beilstein Registry Number | No data available |
| Synonyms | pramiracetam, N-[2-[bis(1-methylethyl)amino]ethyl]-2-oxo-1-pyrrolidineacetamide, Pramiracetam, N-[2-(diisopropylamino)ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide, N-(2-(bis(1-methylethyl)amino)ethyl)-2-oxo-1-pyrrolidineacetamide; CAS Number: 68497-62-1 |
| Molecular Formula | C14H27N3O2 |
| Molecular Weight | 269.38 |
| InChI | InChI=1S/C14H27N3O2/c1-11(2)17(12(3)4)9-7-15-13(18)10-16-8-5-6-14(16)19/h11-12H,5-10H2,1-4H3,(H,15,18) |
| InChI Key | ZULJGOSFKWFVRX-UHFFFAOYSA-N |
| Canonical SMILES | CC(C)N(CCNC(=O)CN1CCCC1=O)C(C)C |
| Patent Information | ||
| Patent ID | Title | Publication Date |
| US2006/241144 | Method for treating apathy syndrome | 2006 |
| EP345787 | Drug in combination with flavor masking agent and method for making same | 1989 |
Physical Data
| Appearance | White powder |
| Solubility | H2O: soluble10mg/mL, clear |
| Flash Point | No data available |
| Refractive index | No data available |
| Sensitivity | No data available |
| Boiling Point, °C | Pressure (Boiling Point), Torr |
| 162 – 164 | 0.2 |
Spectra
| Description (NMR Spectroscopy) | Nucleus (NMR Spectroscopy) | Solvents (NMR Spectroscopy) | Frequency (NMR Spectroscopy), MHz |
| Chemical shifts, Spectrum | 1H | chloroform-d1 | 500 |
| Chemical shifts, Spectrum | 13C | chloroform-d1 | 125 |
| Description (Mass Spectrometry) |
| high resolution mass spectrometry (HRMS), electrospray ionisation (ESI), time-of-flight mass spectra (TOFMS), spectrum |
Route of Synthesis (ROS)
| Conditions | Yield |
| With water In cyclohexane at 20 – 50℃; for 1.5h; Solvent; Experimental Procedure 1.1-1.4; 2.1-2.4; 3.1-3.4; 5.1-5.4; 6.1-6.4 The preparation method of Pramiracetam monohydrate and dihydrate crystal forms includes the following steps. (1) Add 5 g of water to a 25 mL constant pressure dropping funnel for use. (2) Add 30 g of Pramiracetam (Base) and 50 mL of cyclohexane to a 250 mL four-necked flask at room temperature, then heat to 35-50° C. with stirring, and stir for 30 minutes until completely dissolved. (3) Control the temperature to 20-50 °C, add the water of step (1) dropwise to the solution of step (2) for about 30min-1h. After the addition, keep the temperature and stir for 1.5h at the same temperature. Crystallize at 5-15 °C for 12h. (4) After crystallization, filter, rinse the filter cake with 15 mL of cyclohexane, and filter to dryness with suction. The filter cake was taken out and vacuum-dried at 30-42° C. for 12 h to a moisture content of 5.0-7.0%, and a white solid was obtained as Pramiracetam monohydrate (29.1 g, yield 90.92%). | 90.92% |
Safety and Hazards
| Pictogram(s) |  |
| Signal | Warning |
| GHS Hazard Statements | H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] Information may vary between notifications depending on impurities, additives, and other factors. |
| Precautionary Statement Codes | P264, P270, P301+P312, P330, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) |
Other Data
| Transportation | NONH for all modes of transport |
| Under the room temperature and away from light | |
| HS Code | No data available |
| Storage | Under the room temperature and away from light |
| Shelf Life | 2 years |
| Market Price | USD |
| Use Pattern |
| nootropic agent |
| apathy syndrome |
| frontal-subcortical dysfunction |
| stroke |
| Alzheimer’s disease |
| Parkinson’s disease |
| traumatic brain injury |
| chronic hepatitis C infection |
| ingredient of pharmaceutical composition |
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Approved Manufacturers | |
| Caming Pharmaceutical Ltd | http://www.caming.com/ |
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