precorrin-4 C11-methyltransferase EC#: 2.1.1.133; ChemWhat Code: 1376326

Product Name precorrin-4 C11-methyltransferase
Example Structure Example Structure of precorrin-4 C11-methyltransferase EC#: 2.1.1.133
Synonyms Cobalt-precorrin-4 methyltransferase, Methyltransferase (Pseudomonas denitrificans clone pXL151 gene cobF reduced), Methyltransferase, precorrin 2- (Pseudomonas denitrificans clone pXL151), Precorrin-3 methylase, Protein (Pseudomonas denitrificans clone pXL151 gene cobF reduced), S-Adenosyl-L-methionine-dependent cobalt-precorrin-4 transmethylase
EC Number 2.1.1.133
CAS Registry Number 132052-20-1;132053-02-2;9033-25-4
Comments In the aerobic cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. The first of the four steps is carried out by EC 1.14.13.83, precorrin-3B synthase (CobG), yielding precorrin-3B as the product. This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; 2.1.1.152) of the macrocycle, giving rise to precorrin-4, precorrin-5 and precorrin-6A, respectively.
Cofactor
History
Reactions S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin-5.

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