precorrin-6A synthase (deacetylating) EC#: 2.1.1.152; ChemWhat Code: 1376351
| Product Name | precorrin-6A synthase (deacetylating) |
| Example Structure |  |
| Synonyms | CobF, precorrin-6X synthase (deacetylating) |
| EC Number | 2.1.1.152 |
| CAS Registry Number | |
| Comments | In the aerobic cobalamin biosynthesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. The first of the four steps is carried out by EC 1.14.13.83, precorrin-3B synthase (CobG), yielding precorrin-3B as the product. This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; EC 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin-4, precorrin-5 and precorrin-6A, respectively. |
| Cofactor | |
| History | |
| Reactions | S-adenosyl-L-methionine + precorrin-5 + H(2)O = S-adenosyl-L-homocysteine + precorrin-6A + acetate. |
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