protein N-terminal methyltransferase EC#: 2.1.1.244; ChemWhat Code: 1376499
| Product Name | protein N-terminal methyltransferase |
| Example Structure |  |
| Synonyms | alpha-N-methyltransferase, alpha-N-terminal methyltransferase 1, alphaN-methyltransferase, METT11B, METTL11A, METTL11a/C9orf32/Ad-003, N-terminal methyltransferase, N-terminal RCC1 methyltransferase, NMT1, NRMT, NRMT1, Ntm1, NTMT1, peptide N-terminal methyltransferase, protein methyltransferase, protein N-terminal methyltransferase 1, Rkm2, SS alphaN-methyltransferase, SSMT, YBR261C/Tae1 |
| EC Number | 2.1.1.244 |
| CAS Registry Number | |
| Comments | This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. When the terminal amino acid is L-proline, the enzyme catalyses two successive methylations of its ¦Á-amino group. When the first amino acid is either L-alanine or L-serine, the enzyme catalyses three successive methylations. The Pro-Lys in positions 2-3 cannot be exchanged for other amino acids [1,2]. |
| Cofactor | |
| History | |
| Reactions | (1) 3 S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] = 3 S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N- (A,S)PK-[protein]. (2) 2 S-adenosyl-L-methionine + N-terminal-PPK-[protein] = 2 S-adenosyl- L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein]. |
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