(R)-2-hydroxy-4-methylpentanoate CoA-transferase EC#: 2.8.3.24; ChemWhat Code: 1379159

Product Name (R)-2-hydroxy-4-methylpentanoate CoA-transferase
Example Structure Example Structure of (R)-2-hydroxy-4-methylpentanoate CoA-transferase EC#: 2.8.3.24
Synonyms (R)-2-hydroxyisocaproate CoA transferase, HadA
EC Number 2.8.3.24
CAS Registry Number
Comments The enzyme, characterized from the bacterium?Peptoclostridium difficile, participates in an?L-leucine fermentation pathway. The reaction proceeds via formation of a covalent anhydride intermediate between a conserved aspartate residue and the acyl group of the CoA thioester substrate.
Cofactor
History
Reactions 4-methylpentanoyl-CoA + (R)-2-hydroxy-4-methylpentanoate = 4-methylpentanoate + (R)-2-hydroxy-4-methylpentanoyl-CoA.

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