reticuline oxidase EC#: 1.21.3.3; ChemWhat Code: 1376079
| Product Name | reticuline oxidase |
| Example Structure |  |
| Synonyms | (S)-reticuline oxidase, BBE, BBE-like 13, BBE-like 15, BBE-like 28, BBE1, BBL, berberine bridge enzyme, berberine bridge enzyme-like, berberine bridge enzyme-like 28, berberine bridge-forming enzyme, berberine-bridge-forming enzyme, EC 1.5.3.9, flavin-dependent oxidase, monolignol oxidoreductase, reticuline oxidase, tetrahydroprotoberberine synthase |
| EC Number | 1.21.3.3 |
| CAS Registry Number | 152232-28-5 |
| Comments | Contains FAD. The enzyme from the plant Eschscholtzia californica binds the cofactor covalently [3]. Acts on (S)-reticuline and related compounds, converting the N-methyl group into the methylene bridge (‘berberine bridge’) of (S)-tetrahydroprotoberberines. The product of the reaction, (S)-scoulerine, is a precursor of protopine, protoberberine and benzophenanthridine alkaloid biosynthesis in plants. |
| Cofactor | FAD |
| History | |
| Reactions | (S)-reticuline + O(2) = (S)-scoulerine + H(2)O(2). |
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