rifampicin phosphotransferase EC#: 2.7.9.6; ChemWhat Code: 1378990
| Product Name | rifampicin phosphotransferase |
| Example Structure |  |
| Synonyms | rifampin phosphotransferase, RPH, rph4747 |
| EC Number | 2.7.9.6 |
| CAS Registry Number | |
| Comments | |
| Cofactor | |
| History | |
| Reactions | The enzyme, characterized from a diverse collection of Gram-positive bacteria, inactivates the antibiotic rifampicin by phosphorylating it at position 21. The enzyme comprises three domains: two substrate-binding domains (ATP-grasp and rifampicin-binding domains) and a smaller phosphate-carrying?L-histidine swivel domain that transits between the spatially distinct substrate-binding sites during catalysis. |
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