sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) EC#: 1.1.1.153; ChemWhat Code: 1373208

Product Name sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)
Example Structure Example Structure of sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) EC#: 1.1.1.153
Synonyms AKR1B1, MDSPR, reductase, sepiapterin, sepiapterin reductase, SPR, SR
EC Number 1.1.1.153
CAS Registry Number 9059-48-7
Comments This enzyme catalyses the final step in the de novo synthesis of tetrahydrobiopterin from GTP. The enzyme, which is found in higher animals and some fungi and bacteria, produces the erythro form of tetrahydrobiopterin. cf. EC 1.1.1.325, sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming).
Cofactor
History
Reactions (1) L-erythro-7,8-dihydrobiopterin + NADP(+) = sepiapterin + Nadph. (2) L-erythro-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8- tetrahydropterin + 2 Nadph.

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