sphingomyelin synthase EC#: 2.7.8.27; ChemWhat Code: 1378957
| Product Name | sphingomyelin synthase |
| Example Structure |  |
| Synonyms | PC:ceramide cholinephosphotransferase, PC:ceramide phosphocholinetransferase, phosphatidylcholine:ceramide cholinephosphotransferase 1, phosphatidylcholine:ceramide cholinephosphotransferase 2, PlcH, SGMS, SGMS1, Sgms2, SM synthase, SM synthase 1, SMS, SMS1, SMS1-related enzyme, SMS2, SMSr, sphingomyelin synthase 1, sphingomyelin synthase 2, sphingomyelin synthase-related protein, sphingomyelin synthases 1, sphingomyelin synthases 2, sphingomyelin-synthase |
| EC Number | 2.7.8.27 |
| CAS Registry Number | |
| Comments | The reaction can occur in both directions [3]. This enzyme occupies a central position in sphingolipid and glycerophospholipid metabolism [4]. Up- and down-regulation of its activity has been linked to mitogenic and pro-apoptotic signalling in a variety of mammalian cell types [4]. Unlike EC?2.7.8.3, ceramide cholinephosphotransferase, CDP-choline cannot replace phosphatidylcholine as the donor of the phosphocholine moiety of sphingomyelin [2]. |
| Cofactor | |
| History | |
| Reactions | A ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl- sn-glycerol. |
Buy Reagent | |
| No reagent supplier? | Send quick inquiry to ChemWhat |
| Want to be listed here as a reagent supplier? (Paid service) | Click here to contact ChemWhat |
Approved Manufacturers | |
| Want to be listed as an approved manufacturer (Requires approvement)? | Please download and fill out this form and send back to approved-manufacturers@chemwhat.com |
Contact Us for Other Help | |
| Contact us for other information or services | Click here to contact ChemWhat |