spore photoproduct lyase EC#: 4.1.99.14; ChemWhat Code: 1382209
| Product Name | spore photoproduct lyase |
| Example Structure |  |
| Synonyms | Bs SP lyase, Bs SPL, Ca SP lyase, Gt SP lyase, Gt SPL, GTNG_2348, More, SP lyase, SPL, SPL(Ca), spl-1, SplB, SplG, spore photoproduct lyase |
| EC Number | 4.1.99.14 |
| CAS Registry Number | 37290-70-3 |
| Comments | This enzyme is a member of the ‘AdoMet radical’ (radical SAM) family. The enzyme binds a [4Fe-4S] cluster. The cluster is coordinated by 3 cysteines and an exchangeable SAM molecule [3]. The 5′-deoxy-adenosine radical formed after electron transfer from the [4Fe-4S] cluster to the?S-adenosyl-L-methionine, initiates the repair by abstracting the C-6 hydrogen of the spore photoproduct lesion. During the second part of the repair process the SAM molecule is regenerated [3]. |
| Cofactor | iron-sulfur S-adenosyl-L-methionine |
| History | |
| Reactions | (5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine (in double-helical DNA) = thymidylyl-(3′->5′)-thymidylate (in double-helical DNA). |
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