| Synonyms |
(S)-adenosyl-L-methionine:DELTA24(25)-sterol methyl transferase, 24-C-sterol methyltransferase, 24-SMT, 24-sterol C-methyltransferase, C-24 sterol methyltransferase, C-24-methyltransferase, C24-methyltransferase, C24-sterol methyltransferase type 1, DELTA(24,25)-SMT, DELTA24-methyltransferase, DELTA24-sterol methyltransferase, Erg6, Erg6p, GhSMT2-1, GhSMT2-2, methyltransferase, DELTA24-sterol, PbSMT, phytosterol methyltransferase, S-adenosyl-4-methionine:sterol DELTA24-methyltransferase, S-adenosyl-L-methionine:DELTA24(23)-sterol methyltransferase, SMT, SMT protein, SMT-2, SMT-3, SMT1, SMT2-1, sterol 24-C-methyltransferase, sterol 24C-methyltransferases, sterol C24-methyltransferase, sterol C24-methyltransferases, sterol methyltransferase, STM, TbSMT, zymosterol 24-methyltransferase, zymosterol-24(25)-methyltransferase, zymosterol-24-methyltransferase |
| Comments |
Requires glutathione. Acts on a range of sterols with a 24(25)-double bond in the sidechain. While zymosterol is the preferred substrate it also acts on desmosterol, 5¦Á-cholesta-7,24-dien-3¦Â-ol, 5¦Á-cholesta-5,7,24-trien-3¦Â-ol, 4¦Á-methylzymosterol and others. S-Adenosyl-L-methionine attacks the Si-face of the 24(25) double bond and the C-24 hydrogen is transferred to C-25 on the Re face of the double bond. |
