taxadiene 5alpha-hydroxylase EC#: 1.14.99.37; ChemWhat Code: 1375918
| Product Name | taxadiene 5alpha-hydroxylase |
| Example Structure |  |
| Synonyms | 5alphaCYP, CYP725A4, oxygenase, taxadiene 5-mono-, taxa-4(5),11(12)-diene 5-hydroxylase, taxa-4(5),11(12)-diene 5alpha-hydroxylase, taxadien-5alpha-hydroxylase, taxadiene 5-hydroxylase, taxadiene 5-monooxygenase, taxadiene synthase, taxadiene-5alpha-hydroxylase |
| EC Number | 1.14.99.37 |
| CAS Registry Number | 9035-51-2 |
| Comments | This microsomal cytochrome-P450-dependent enzyme is involved in the biosynthesis of the diterpenoid antineoplastic drug Taxol (paclitaxel). The reaction includes rearrangement of the 4(5)-double bond to a 4(20)-double bond, possibly through allylic oxidation. |
| Cofactor | heme-thiolate |
| History | |
| Reactions | Taxa-4,11-diene + AH(2) + O(2) = taxa-4(20),11-dien-5-alpha-ol + A + H(2)O. |
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