tetrachloroethene reductive dehalogenase EC#: 1.21.99.5; ChemWhat Code: 1376102
| Product Name | tetrachloroethene reductive dehalogenase |
| Example Structure |  |
| Synonyms | 1,2,4,5-TeCB reductive dehalogenase, dceA6, dehalogenase, polychloroethene, mbrA, PCE dehalogenase, PCE reductase, PCE reductive dehalogenase, PCE-dechlorinating enzyme, PCE-RD, PCE-RDase, PCE-reductive dehalogenase, PCE/PCB RDase, PCE/TCERD, PceA, pceA gene product, PceA1, PceA2, PceATCE, PceC, pceC gene product, PCER, PCERD, perchloroethylene dehalogenase, polychloroethane dehalogenase, RD11, RD8, RDase, RDH, RdhA, RdhA3, reductive dehalogenase, reductive PCE dehalogenase, Ssed_3769, TcbA, TCE dehalogenase, TCE reductase, tetrachlorobenzene dehalogenase, tetrachloroethene (PCE) dehalogenase, tetrachloroethene (PCE) reductive dehalogenase, tetrachloroethene and trichloroethene dehalogenase, tetrachloroethene dehalogenase, tetrachloroethene reductase, tetrachloroethene reductive dehalogenase, tetrachloroethene reductive dehalogenase catalytic subunit PceA, tetrachloroethylene reductase, ThMA, trichloroethene dehalogenase |
| EC Number | 1.21.99.5 |
| CAS Registry Number | 163913-51-7 |
| Comments | This enzyme allows the common pollutant tetrachloroethene to support bacterial growth and is responsible for disposal of a number of chlorinated hydrocarbons by this organism. The reaction occurs in the reverse direction. The enzyme also reduces trichloroethene to dichloroethene. Although the physiological reductant is unknown, the supply of reductant in some organisms is via reduced menaquinone, itself formed from molecular hydrogen, via EC 1.12.5.1, hydrogen:quinone oxidoreductase. The enzyme contains a corrinoid and two iron-sulfur clusters. Methylviologen can act as electron donor. |
| Cofactor | iron-sulfur |
| History | |
| Reactions | Trichloroethene + chloride + acceptor = tetrachloroethene + reduced acceptor. |
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