tetrahydromethanopterin S-methyltransferase EC#: 2.1.1.86; ChemWhat Code: 1376260
| Product Name | tetrahydromethanopterin S-methyltransferase |
| Example Structure |  |
| Synonyms | 5-methyl-5,6,7,8-tetrahydromethanopterin:coenzyme M methyltransferase, 5-methyl-5,6,7,8-tetrahydrosarcinapterin:coenzyme M methyltransferase, CH3-THMPT:HS-CoM methyltransferase, CH3-THMPT:HSCoM methyltransferase, CmtA, cytoplasmic methyltransferase A, H,MPT:coenzyme M methyltransferase, H4MPT, MA4384, methyl-tetrahydromethanopterin methyltransferase, methyl-tetrahydromethanopterin:coenzyme-M methyltransferase, methyl-tetrahydromethanopterin:CoM methyltransferase, methyltransferase, tetrahydromethanopterin, MTR, MtrA-H, N5-methyltetrahydromethanopterin: coenzyme M methyltransferase, N5-methyltetrahydromethanopterin:coenzyme M methyltransferase, tetrahydromethanopterin methyltransferase |
| EC Number | 2.1.1.86 |
| CAS Registry Number | 103406-60-6 |
| Comments | Involved in the formation of methane from CO2 in methanogenic archaea. The reaction involves the export of one or two sodium ions. The enzyme from the archaeon Methanobacterium thermoautotrophicum is a membrane-associated multienzyme complex composed of eight different subunits, and contains a 5′-hydroxybenzimidazolyl-cobamide prosthetic group, to which the methyl group is attached during the transfer. A soluble enzyme that is induced by the presence of CO has been reported as well. |
| Cofactor | |
| History | |
| Reactions | 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(In) = 5,6,7,8-tetrahydromethanopterin + 2-(methylsulfanyl)ethane-1-sulfonate + 2 Na(+)(Out). |
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