thyroxine 5-deiodinase EC#: 1.21.99.3; ChemWhat Code: 1376099
| Product Name | thyroxine 5-deiodinase |
| Example Structure |  |
| Synonyms | 5′-deiodinase, D3, deiodinase, deiodinase 3, deiodinase, thyroxine 5-, deiodinase-3, diiodothyronine 5′-deiodinase, Dio, Dio3, Dio3a, Dio3b, ID-3, iodothyronine 5-deiodinase, iodothyronine deiodinase type III, iodothyronine inner ring monodeiodinase, iodothyronine monodeiodinase, ITHD, T4-5′-deiodinase, T4-5-deiodinase, thyroxine 5-deiodinase, type 3 deiodinase, type 3 iodothyronine 5-deiodinase, type 3 iodothyronine deiodinase, type III deiodinase, type III iodothyronine deiodinase, type-3 deiodinase, zD3 |
| EC Number | 1.21.99.3 |
| CAS Registry Number | |
| Comments | The enzyme activity has only been demonstrated in the direction of 5-deiodination. This removal of the 5-iodine, i.e. from the inner ring, largely inactivates the hormone thyroxine. Formerly EC 1.97.1.11. |
| Cofactor | |
| History | |
| Reactions | 3,3′,5′-triiodo-L-thyronine + iodide + acceptor + H(+) = L-thyroxine + reduced acceptor. |
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