trimethylamine-corrinoid protein Co-methyltransferase EC#: 2.1.1.250; ChemWhat Code: 1376508
| Product Name | trimethylamine-corrinoid protein Co-methyltransferase |
| Example Structure |  |
| Synonyms | DSY3156 protein, glycine betaine:cob(I)alamin methyltransferase, MMA methyltransferase 1, MMA methyltransferase 2, MtgB, MttB, mttB1C1, mttB2C2, nonpyrrolysine MttB homolog, TMA methyltransferase, TMA:CoM methyltransferase, trimethylamine methyltransferase |
| EC Number | 2.1.1.250 |
| CAS Registry Number | |
| Comments | The enzyme, which catalyses the transfer of a methyl group from trimethylamine to a trimethylamine-specific corrinoid protein (MttC), is involved in methanogenesis from trimethylamine. The enzyme contains the unusual amino acid pyrrolysine [2]. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. The methylated corrinoid protein is substrate for EC 2.1.1.247, methylated methylamine-specific corrinoid protein:coenzyme M methyltransferase. |
| Cofactor | |
| History | |
| Reactions | Trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein] = a [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine. |
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