tRNA (adenine57-N1/adenine58-N1)-methyltransferase EC#: 2.1.1.219; ChemWhat Code: 1376459
| Product Name | tRNA (adenine57-N1/adenine58-N1)-methyltransferase |
| Example Structure |  |
| Synonyms | bi-specific tRNA adenine-N1, A57-A58-methyltransferase, bi-specific tRNA adenine-N1, A57-A58-MTase, PAB0283 protein, PabTrmI, PYRAB04300, TrmI, tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase, tRNA (m1A) methyltransferase, tRNA m1A57/58 methyltransferase, tRNA(m1A57/58)-methyltransferase |
| EC Number | 2.1.1.219 |
| CAS Registry Number | |
| Comments | The enzyme catalyses the formation of N1-methyladenine at two adjacent positions (57 and 58) in the T-loop of certain tRNAs (e.g. tRNAAsp). Methyladenosine at position 57 is an obligatory intermediate for the synthesis of methylinosine, which is commonly found at position 57 of archaeal tRNAs. Formerly EC 2.1.1.36. |
| Cofactor | |
| History | |
| Reactions | 2 S-adenosyl-L-methionine + adenine(57)/adenine(58) in tRNA = 2 S-adenosyl-L-homocysteine + N(1)-methyladenine(57)/N(1)- methyladenine(58) in tRNA. |
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