cytosine-5 RNA methyltransferase, hTrm4, NOP2/Sun domain family member 2, NSUN2, RNA:m5C methyltransferase, SAKI, substrate of AIM-1/Aurora kinase B
EC Number
2.1.1.203
CAS Registry Number
Comments
The human enzyme is specific for C5-methylation of cytosine34 in tRNA precursors. The intron in the human pre-tRNALeu(CAA) is indispensable for the C5-methylation of cytosine in the first position of the anticodon. It is not able to form 5-methylcytosine at positions 48 and 49 of human and yeast tRNA precursors [1].
Cofactor
History
Reactions
S-adenosyl-L-methionine + cytosine(34) in tRNA precursor = S-adenosyl-L- homocysteine + 5-methylcytosine(34) in tRNA precursor.
