tRNA (cytosine38-C5)-methyltransferase EC#: 2.1.1.204; ChemWhat Code: 1376435
| Product Name | tRNA (cytosine38-C5)-methyltransferase |
| Example Structure |  |
| Synonyms | DNA methyltransferase 2, DnmA, Dnmt2, DNMT2 methyltransferase, hDNMT2, PMT1, pombe methyltransferase 1, transfer RNA aspartic acid methyltransferase 1, TRDMT1, tRNA-aspartic acid methyltransferase 1 |
| EC Number | 2.1.1.204 |
| CAS Registry Number | |
| Comments | The eukaryotic enzyme catalyses methylation of cytosine38 in the anti-codon loop of tRNAAsp(GTC), tRNAVal(AAC) and tRNAGly(GCC). Methylation by Dnmt2 protects tRNAs against stress-induced cleavage by ribonuclease [3]. |
| Cofactor | |
| History | |
| Reactions | S-adenosyl-L-methionine + cytosine(38) in tRNA = S-adenosyl-L- homocysteine + 5-methylcytosine(38) in tRNA. |
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