tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase EC#: 2.1.1.215; ChemWhat Code: 1376452

Product Name tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase
Example Structure Example Structure of tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase EC#: 2.1.1.215
Synonyms multisite-specific tRNA methyltransferase, Trm1, Trm1[tRNA (m2(2)G26) methyltransferase], tRNA (m2(2)G26) methyltransferase, tRNA (N2,N2-guanine)-dimethyltransferase, tRNA:m22G26-methyltransferase
EC Number 2.1.1.215
CAS Registry Number
Comments The enzyme from Aquifex aeolicus is similar to the TRM1 methyltransferases of archaea and eukarya (see EC 2.1.1.216, tRNA (guanine26-N2)-dimethyltransferase). However, it catalyses the double methylation of guanines at both positions 26 and 27 of tRNA.
Cofactor
History
Reactions 4 S-adenosyl-L-methionine + guanine(26)/guanine(27) in tRNA = 4 S-adenosyl-L-homocysteine + N(2)-dimethylguanine(26)/N(2)- dimethylguanine(27) in tRNA.

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