tRNA (guanine37-N1)-methyltransferase EC#: 2.1.1.228; ChemWhat Code: 1376474
| Product Name | tRNA (guanine37-N1)-methyltransferase |
| Example Structure |  |
| Synonyms | MJ0883, Ta0997, transfer RNA (m1G37) methyltransferase, Trm1, TRM5, Trm5p, TrmD, tRNA (guanosine-1) methyltransferase, tRNA (m1G37) methyltransferase, tRNA m1G37 methyltransferase, tRNA methyltransferase 5, tRNA methyltransferase D, tRNA(m1G37) methyltransferase, tRNA(m1G37) MTase, tRNA(m1G37)methyltransferase, tRNA-(N1G37) methyltransferase |
| EC Number | 2.1.1.228 |
| CAS Registry Number | |
| Comments | This enzyme is important for the maintenance of the correct reading frame during translation. Unlike TrmD from Escherichia coli, which recognizes the G36pG37 motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37 [4]. |
| Cofactor | |
| History | |
| Reactions | S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA. |
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