tRNA (guanine9-N1)-methyltransferase EC#: 2.1.1.221; ChemWhat Code: 1376463
| Product Name | tRNA (guanine9-N1)-methyltransferase |
| Example Structure |  |
| Synonyms | m1G9 methyltransferase, TK0422p, Trm10, Trm10p (ambiguous), TRMT10A, tRNA (guanine-N(1)-)-methyltransferase, tRNA m1G9 methyltransferase, tRNA m1G9 MTase, tRNA(m1G9/m1A9)-methyltransferase, tRNA(m1G9/m1A9)Mtase |
| EC Number | 2.1.1.221 |
| CAS Registry Number | |
| Comments | The enzyme from Saccharomyces cerevisiae specifically methylates guanine9 [1,2]. The bifunctional enzyme from Thermococcus kodakaraensis also catalyses the methylation of adenine9 in tRNA (cf. EC 2.1.1.218, tRNA (adenine9-N1)-methyltransferase) [1]. |
| Cofactor | |
| History | |
| Reactions | S-adenosyl-L-methionine + guanine(9) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(9) in tRNA |
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