tRNA (pseudouridine54-N1)-methyltransferase EC#: 2.1.1.257; ChemWhat Code: 1376516
| Product Name | tRNA (pseudouridine54-N1)-methyltransferase |
| Example Structure |  |
| Synonyms | COG 1901, COG1901, DUF358, DUF358/Mj1640, Emg1, Hvo_1989, m1-pseudouridine methyltransferase, m1G, m1PSI methyltransferase, M3U, Mja_1640, MjNep1, Nep1, Pfam DUF358, pseudouridine N1-specific methyltransferase, pseudouridine-N1-specific methyltransferase, ribosome assembly factor Nep1, SAM-dependent N1-pseudouridine methyltransferase, TrmY, TrmY protein |
| EC Number | 2.1.1.257 |
| CAS Registry Number | |
| Comments | While this archaeal enzyme is specific for the 54 position and does not methylate pseudouridine at position 55, the presence of pseudouridine at position 55 is necessary for the efficient methylation of pseudouridine at position 54 [2,3]. |
| Cofactor | |
| History | |
| Reactions | S-adenosyl-L-methionine + pseudouridine(54) in tRNA = S-adenosyl-L- homocysteine + N(1)-methylpseudouridine(54) in tRNA. |
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