tRNAIle2-agmatinylcytidine synthase EC#: 6.3.4.22; ChemWhat Code: 1383850

Product Name tRNAIle2-agmatinylcytidine synthase
Example Structure Example Structure of tRNAIle2-agmatinylcytidine synthase EC#: 6.3.4.22
Synonyms AF2259, TiaS, tRNAIle-2-agmatinylcytidine synthetase, tRNAIle-agm2C synthetase, tRNAIle-agmatidine synthetase
EC Number 6.3.4.22
CAS Registry Number
Comments The enzyme from the archaeon?Archaeoglobus fulgidus?modifies the wobble base of the CAU anticodon of the archaeal tRNAIle2?at the oxo group in position 2 of cytidine34. This modification is crucial for accurate decoding of the genetic code. In bacteria EC?6.3.4.19, tRNAIle-lysidine synthase, catalyses the modification of [tRNAIle2]-cytidine34?to [tRNAIle2]-lysidine34.
Cofactor
History
Reactions Atp + agmatine + (tRNA(Ile)(2))-cytidine(34) + H(2)O = (tRNA(Ile)(2))-2- agmatinylcytidine(34) + Amp + 2 phosphate.

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