tubulin-tyrosine ligase EC#: 6.3.2.25; ChemWhat Code: 1383759
| Product Name | tubulin-tyrosine ligase |
| Example Structure |  |
| Synonyms | Synthetase, tubulin-tyrosine, TTL, TTLase, tubulin tyrosine ligase, tubulin-tyrosine ligase, tubulin-tyrosine-ligase, Tubulin:tyrosine ligase, tubuline-tyrosine ligase, Tyrosyltubulin ligase |
| EC Number | 6.3.2.25 |
| CAS Registry Number | |
| Comments | L-Tyrosine is linked via a peptide bond to the C-terminus of de-tyrosinated ¦Á-tubulin (des-Tyr¦Ø-¦Á-tubulin). The enzyme is highly specific for ¦Á-tubulin and moderately specific for ATP and?L-tyrosine.?L-Phenylalanine and 3,4-dihydroxy-L-phenylalanine are transferred but with higher?Km?values. |
| Cofactor | |
| History | |
| Reactions | Atp + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + adp + phosphate. |
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