UDP-N-acetylmuramate-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase EC#: 6.3.2.45; ChemWhat Code: 1383786

Product Name UDP-N-acetylmuramate-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase
Example Structure Example Structure of UDP-N-acetylmuramate-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase EC#: 6.3.2.45
Synonyms Mpl, murein peptide ligase, UDP-MurNAc:L-Ala-gamma-D-Glu-meso-A2pm ligase, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase, UDP-N-alpha-D-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (ADP-forming), yjfG
EC Number 6.3.2.45
CAS Registry Number
Comments The enzyme catalyses the reincorporation into peptidoglycan of the tripeptide?L-alanyl-¦Ã-D-glutamyl-2,6-meso-diaminoheptanedioate released during the maturation and constant remodeling of this bacterial cell wall polymer that occur during cell growth and division. The enzyme can also use the tetrapeptide?L-alanyl-¦Ã-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanine or the pentapeptide?L-alanyl-¦Ã-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanyl-D-alanine?in vivo?and?in vitro. Requires Mg2+.
Cofactor Mg2+
History
Reactions Atp + UDP-N-acetyl-alpha-D-muramate + L-alanyl-gamma-D-glutamyl-meso-2,6- diaminoheptanedioate = Adp + phosphate + UDP-N-acetylmuramoyl-L-alanyl- gamma-D-glutamyl-meso-2,6-diaminoheptanedioate.

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