vitamin-K-epoxide reductase (warfarin-insensitive) EC#: 1.17.4.5; ChemWhat Code: 1376010

Product Name vitamin-K-epoxide reductase (warfarin-insensitive)
Example Structure Example Structure of vitamin-K-epoxide reductase (warfarin-insensitive) EC#: 1.17.4.5
Synonyms non-VKOR, reductase, vitamin K epoxide (warfarin-insensitive), vitamin K 2,3 epoxide reductase, vitamin K epoxide reductase, vitamin K epoxide reductase (warfarin-insensitive), vitamin K epoxide reductase-like1, vitamin KO reductase, VKOR, VKOR-like1, VKORC1L1, VKORL1
EC Number 1.17.4.5
CAS Registry Number 97089-80-0
Comments Vitamin K 2,3-epoxide is reduced to 3-hydroxy- (and 2-hydroxy-) vitamin K by 1,4-dithiothreitol, which is oxidized to a disulfide. Not inhibited by warfarin [cf. EC 1.17.4.4, vitamin-K-epoxide reductase (warfarin-sensitive)].
Cofactor
History
Reactions 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4- naphthoquinone + 1,4-dithiothreitol.

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